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PMID: 11584303 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

PKB/AKT: functional insights from genetic models.

Nature reviews. Molecular cell biology ·Vol. 2 ·No. 10 ·2001-10-00 ·Pages 760-8

Scheid MP, Woodgett JR

Abstract

Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.

MeSH Terms

Amino Acid Sequence Animals Drosophila/genetics Drosophila Proteins Enzyme Activation Humans Models, Biological Models, Genetic Molecular Sequence Data Phosphatidylinositol 3-Kinases/metabolism Protein Serine-Threonine Kinases Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins/chemistry,genetics,metabolism Proto-Oncogene Proteins c-akt Sequence Alignment Sequence Homology, Amino Acid Substrate Specificity

Chemicals

Drosophila Proteins Proto-Oncogene Proteins Protein-Tyrosine Kinases AKT1 protein, human Akt1 protein, Drosophila Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Scheid M P

Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

Woodgett J R

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/35096067

Published

2001-10-00

Pages

760-8

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/35096067 View journal details

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