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PMID: 11601733 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics.

Journal of biomechanical engineering ·Vol. 123 ·No. 5 ·2001-10-00 ·Pages 474-84

Finol EA, Amon CH

Abstract

Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Physiologically realistic aortic blood flow is simulated under pulsatile conditions for the range of time-averaged Reynolds numbers 50< or =Re(m)< or =300, corresponding to a range of peak Reynolds numbers 262.5< or =Re(peak) < or = 1575. The vortex dynamics induced by pulsatile flow in AAAs is characterized by a sequence of five different flow phases in one period of the flow cycle. Hemodynamic disturbance is evaluated for a modified set of indicator functions, which include wall pressure (p(w)), wall shear stress (tau(w)), and Wall Shear Stress Gradient (WSSG). At peak flow, the highest shear stress and WSSG levels are obtained downstream of both aneurysms, in a pattern similar to that of steady flow. Maximum values of wall shear stresses and wall shear stress gradients obtained at peak flow are evaluated as a function of the time-average Reynolds number resulting in a fourth order polynomial correlation. A comparison between predictions for steady and pulsatile flow is presented, illustrating the importance of considering time-dependent flow for the evaluation of hemodynamic indicators.

MeSH Terms
Aortic Aneurysm, Abdominal/etiology,physiopathology Aortic Rupture/etiology,physiopathology Biomechanical Phenomena Biomedical Engineering Blood Flow Velocity Computer Simulation Hemodynamics/physiology Hemorheology Humans Models, Cardiovascular Pulsatile Flow
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Finol E A
Mechanical Engineering, Biomedical and Health Engineering, and Institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA 15213-3890, USA.
Amon C H
Article Info
Journal
Journal of biomechanical engineering
Abbr.
J Biomech Eng
ISSN
0148-0731
Published
2001-10-00
Pages
474-84
Language
English
Region
United States
NLM ID
7909584
Subset
IM
Analysis Services
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