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PMID: 1161061 Published · ppublish English Comparative Study Journal Article

Influence of papaverine, D600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 289 ·No. 4 ·1975-00-00 ·Pages 409-18

Schümann HJ, Görlitz BD, Wagner J

Abstract

The effects of papaverine and of the organic calcium-antagonistic agents D 600 and nifedipine on the contraction induced by noradrenaline and calcium were studied on the isolated aorta and mesenteric artery. The affinities of both agonists, given as pD2-values, were significantly higher on the aorta than on the mesenteric artery. Under our experimental conditions D 600, nifedipine and papaverine were found to act as antagonists against calcium and noradrenaline in a non-competitive fashion. In either vessel, the calcium-antagonistic activity of D 600 and nifedipine was about 1000-fold greater than that of papaverine, whereas their antagonistic activity against noradrenaline was bout 1000-times weaker, i.e. D 600 as well as nifedipine were about equipotent with papaverine. The comparison between the calcium- and the noradrenaline-antagonistic activity offers the possiblity to evaluate the specifcity of calcium antagonistic agents.

MeSH Terms
Animals Anti-Arrhythmia Agents Aorta, Thoracic/drug effects Calcium/antagonists & inhibitors Calcium Chloride/pharmacology Dose-Response Relationship, Drug Gallopamil/pharmacology In Vitro Techniques Mesenteric Arteries/drug effects Muscle Contraction/drug effects Muscle, Smooth/drug effects Nifedipine/pharmacology Norepinephrine/antagonists & inhibitors,pharmacology Papaverine/pharmacology Pyridines/pharmacology Rabbits Verapamil/analogs & derivatives
Chemicals
Anti-Arrhythmia Agents Pyridines Gallopamil Verapamil Papaverine Nifedipine Calcium Chloride Calcium Norepinephrine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schümann H J
Görlitz B D
Wagner J
References (15)
15 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00508414
Published
1975-00-00
Pages
409-18
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00508414 View journal details
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