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PMID: 116282 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

The effect of high dose oxprenolol on stress-induced physical and psychophysiological variables.

Psychopharmacology ·Vol. 64 ·No. 3 ·1979-09-00 ·Pages 365-9

Farhoumand N, Harrison J, Pare CM, Turner P, Wynn S

Abstract

The effects of oral oxprenolol (480 mg) and lorazepam (2 mg) on skin conductance, reaction time, critical flicker frequency and self-rating visual analogue scales for anxiety, sedation and concentration were investigated in 6 healthy male volunteers. Oxprenolol exerted a central action similar to lorazepam as shown by a significant lowering of skin conductance and decrease in the number of spontaneous fluctuations during stress, impaired critical flicker frequency and decrease in alertness with reduced concentration.

MeSH Terms
Adolescent Adult Blood Pressure/drug effects Dose-Response Relationship, Drug Double-Blind Method Flicker Fusion/drug effects Galvanic Skin Response/drug effects Heart Rate/drug effects Humans Lorazepam/pharmacology Male Oxprenolol/pharmacology Reaction Time/drug effects Stress, Psychological/physiopathology,psychology Time Factors
Chemicals
Oxprenolol Lorazepam
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Farhoumand N
Harrison J
Pare C M
Turner P
Wynn S
References (12)
12 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00427526
Published
1979-09-00
Pages
365-9
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00427526 View journal details
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