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PMID: 11684439 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Cellular senescence as a tumor-suppressor mechanism.

Trends in cell biology ·Vol. 11 ·No. 11 ·2001-11-00 ·Pages S27-31

Campisi J

Abstract

Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.

MeSH Terms
Animals Cell Division Cell Transformation, Neoplastic Cellular Senescence/genetics,physiology Genes, Tumor Suppressor/physiology Genes, p53/genetics Humans Neoplasms/etiology,physiopathology Phenotype Retinoblastoma Protein/genetics,metabolism Telomere/metabolism
Chemicals
Retinoblastoma Protein
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Campisi J
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA. [email protected]
Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
0962-8924
DOI
10.1016/s0962-8924(01)02151-1
Email
[email protected]
Published
2001-11-00
Pages
S27-31
Language
English
Region
England
NLM ID
9200566
Subset
IM
External Links
PubMed source DOI: 10.1016/s0962-8924(01)02151-1 View journal details
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