Home LiteratureArticle Details
PMID: 11687795 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Assembly of microarrays for genome-wide measurement of DNA copy number.

Nature genetics ·Vol. 29 ·No. 3 ·2001-11-00 ·Pages 263-4

Snijders AM, Nowak N, Segraves R, Blackwood S, Brown N, Conroy J, Hamilton G, Hindle AK, Huey B, Kimura K, Law S, Myambo K, Palmer J, Ylstra B, Yue JP, Gray JW, Jain AN, Pinkel D, Albertson DG

Abstract

We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

MeSH Terms
Aneuploidy Chromosomes, Artificial, Bacterial/genetics Cloning, Molecular Female Gene Dosage Genome, Human Genomics/methods Humans Male Oligonucleotide Array Sequence Analysis/methods Polymerase Chain Reaction Polyploidy Tumor Cells, Cultured X Chromosome/genetics
Authors & Affiliations
19 authors, click to expand affiliations / ORCID
Snijders A M
Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.
Nowak N
Segraves R
Blackwood S
Brown N
Conroy J
Hamilton G
Hindle A K
Huey B
Kimura K
Law S
Myambo K
Palmer J
Ylstra B
Yue J P
Gray J W
Jain A N
Pinkel D
Albertson D G
Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng754
Published
2001-11-00
Pages
263-4
Language
English
Region
United States
NLM ID
9216904
Subset
IM
Grants
NCI NIH HHS · CA58207 · United States
NCI NIH HHS · CA80314 · United States
NCI NIH HHS · CA83040 · United States
NCI NIH HHS · CA84118 · United States
NICHD NIH HHS · HD17665 · United States
External Links
PubMed source DOI: 10.1038/ng754 View journal details
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