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PMID: 11699941 Published · ppublish English Journal Article Review

Hippocampal GABAergic interneurons: a physiological perspective.

Neurochemical research ·Vol. 26 ·No. 8-9 ·2001-09-00 ·Pages 899-905

Buzsáki G

Abstract

Oscillations within and across neuronal systems are believed to serve various complex functions, such as perception, cognition, movement initiation, plasticity and memory. GABAergic interneurons and their inhibitory synapses play a major role in these oscillatory patterns. Networks of inhibitory interneurons impose a coordinated oscillatory "context" for the "content" carried by networks of principal cells. This hypothesis implies that GABAergic neuronal "supernetworks" may cooperatively entrain large populations of pyramidal cells throughout the forebrain. Experiments on hippocampal interneurons are reviewed and possible solutions for some of these complex functions are illustrated.

MeSH Terms
Hippocampus/cytology,metabolism Interneurons/metabolism gamma-Aminobutyric Acid/metabolism
Chemicals
gamma-Aminobutyric Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Buzsáki G
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA. [email protected]
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1023/a:1012324231897
Email
[email protected]
Published
2001-09-00
Pages
899-905
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1012324231897 View journal details
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