DNA from eukaryotic cells contains unusually long pyrimidine sequences.

Canadian journal of biochemistry ·Vol. 53 ·No. 5 ·1975-05-00 ·Pages 640-3

Birnboim HC, Straus NA

Abstract

Analysis of DNA samples from several different organisms revealed the presence of unexpectedly long pyrimidine tracts (polypyrimidine), ranging in size from about 25 to 200 nucleotides in length. This fraction of the DNA accounted for 0.07-0.8 percent of the total thymidine residues. Pyrimidine clusters of this length and amount would not be expected on a random basis, suggesting they may have been conserved during evolution because they are required for a specialized function(s).

MeSH Terms

Animals Base Sequence Biological Evolution Cattle Cells, Cultured Cricetinae DNA/metabolism DNA, Bacterial/metabolism DNA, Neoplasm/metabolism DNA, Viral/metabolism HeLa Cells/metabolism Humans L Cells/metabolism Pyrimidine Nucleotides/metabolism Rabbits Thymidine/metabolism Uridine/metabolism

Chemicals

DNA, Bacterial DNA, Neoplasm DNA, Viral Pyrimidine Nucleotides DNA Thymidine Uridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Birnboim H C

Straus N A

Article Info

Journal

Canadian journal of biochemistry

Abbr.

Can J Biochem

ISSN

0008-4018

DOI

10.1139/o75-088

Published

1975-05-00

Pages

640-3

Language

English

Region

Canada

NLM ID

0421034

Subset

External Links

PubMed source DOI: 10.1139/o75-088

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DNA from eukaryotic cells contains unusually long pyrimidine sequences.

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