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PMID: 11708889 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.

Seminars in immunology ·Vol. 13 ·No. 6 ·2001-12-00 ·Pages 339-45

Cox D, Greenberg S

Abstract

Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 microm. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc(gamma)Rs ).

MeSH Terms
ADP-Ribosylation Factor 6 ADP-Ribosylation Factors/physiology Actins/metabolism Animals Cytoskeleton/physiology Enzyme Precursors/physiology Humans Intracellular Signaling Peptides and Proteins Isoenzymes/metabolism Phagocytosis/physiology Phosphatidylinositol 3-Kinases Phospholipase C gamma Phosphorylation Protein-Tyrosine Kinases/physiology Receptors, IgG/physiology Signal Transduction Syk Kinase Type C Phospholipases/metabolism src-Family Kinases/physiology
Chemicals
ADP-Ribosylation Factor 6 Actins Enzyme Precursors Intracellular Signaling Peptides and Proteins Isoenzymes Receptors, IgG Protein-Tyrosine Kinases SYK protein, human Syk Kinase src-Family Kinases Type C Phospholipases Phospholipase C gamma ADP-Ribosylation Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cox D
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA. [email protected]
Greenberg S
Article Info
Journal
Seminars in immunology
Abbr.
Semin Immunol
ISSN
1044-5323
DOI
10.1006/smim.2001.0330
Email
[email protected]
Published
2001-12-00
Pages
339-45
Language
English
Region
England
NLM ID
9009458
Subset
IM
External Links
PubMed source DOI: 10.1006/smim.2001.0330 View journal details
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