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PMID: 11717384 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 21 ·No. 23 ·2001-12-01 ·Pages 9499-505

Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldonado R

Abstract

The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.

MeSH Terms
Analgesia Analgesics, Opioid/pharmacology Animals Avoidance Learning/drug effects Behavior, Animal/drug effects Brain Chemistry Dronabinol/pharmacology Dynorphins/analysis,deficiency,genetics Enkephalins/deficiency,genetics Female Gene Targeting Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Morphine/pharmacology Motivation Motor Activity/drug effects,genetics Narcotics/pharmacology Pain Measurement/drug effects Protein Precursors/deficiency,genetics Receptors, Opioid, kappa/deficiency,drug effects,genetics Spatial Behavior/drug effects Substance-Related Disorders/physiopathology
Chemicals
Analgesics, Opioid Enkephalins Narcotics Protein Precursors Receptors, Opioid, kappa Dynorphins Morphine Dronabinol preproenkephalin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Zimmer A
Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Valjent E
Konig M
Zimmer A M
Robledo P
Hahn H
Valverde O
Maldonado R
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2001-12-01
Pages
9499-505
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6763924
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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