Inhibitory effect of flavin mononucleotide on the hemolysis of rabbit erythrocytes by staphylococcal alpha-toxin.

Infection and immunity ·Vol. 12 ·No. 3 ·1975-09-00 ·Pages 696-7

Kato I, Sakoda K, Saito M, Suzuki Y, Watanabe M

Abstract

Flavin mononucleotide diminished the hemolytic action of staphylococcal alpha-toxin on rabbit erythrocytes by competitive inhibition, probably by its interaction with the alpha-toxin binding sites on the cell membrane.

MeSH Terms

Animals Binding Sites Binding, Competitive Cell Membrane/immunology Erythrocytes/drug effects Flavin Mononucleotide/pharmacology Hemolysis/drug effects Pronase Rabbits Riboflavin/metabolism Staphylococcus aureus/immunology Toxins, Biological/pharmacology

Chemicals

Toxins, Biological Flavin Mononucleotide Pronase Riboflavin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kato I

Sakoda K

Saito M

Suzuki Y

Watanabe M

References (3)

3 references, click to expand

Isolation and composition of staphylococcal alpha toxin.
J Gen Microbiol. 1963 Mar;30:455-68 PMID: 13967637
Effect of diphtheria toxin on lysosome activity in leukocytes and Ehrlich ascites tumor cells.
Jpn J Exp Med. 1970 Apr;40(2):87-100 PMID: 5311235
Purification and some properties of staphylococcal alpha-toxin.
Jpn J Exp Med. 1974 Apr;44(2):165-78 PMID: 4546168

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.12.3.696-697.1975

Published

1975-09-00

Pages

696-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC415342

Subset

External Links

PubMed source DOI: 10.1128/iai.12.3.696-697.1975 PMC Full Text View journal details

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Inhibitory effect of flavin mononucleotide on the hemolysis of rabbit erythrocytes by staphylococcal alpha-toxin.

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