Resistance is futile: assimilation of cellular machinery by HIV-1.

Immunity ·Vol. 15 ·No. 5 ·2001-11-00 ·Pages 687-90

Perez OD, Nolan GP

Abstract

HIV-1 budding appears to require Vps4 and Tsg101-two proteins that have links to endosomal sorting machinery. A picture emerges wherein divergent viruses recruit endosomal proteins like Tsg101 to gain access to ubiquitin processes that play a crucial role during viral budding.

MeSH Terms

Acquired Immunodeficiency Syndrome/virology Adenosine Triphosphatases Carrier Proteins/physiology DNA-Binding Proteins/physiology Endosomal Sorting Complexes Required for Transport Endosomes/physiology Fungal Proteins/physiology HIV-1/physiology Humans Saccharomyces cerevisiae Proteins Transcription Factors/physiology Virus Replication

Chemicals

Carrier Proteins DNA-Binding Proteins Endosomal Sorting Complexes Required for Transport Fungal Proteins Saccharomyces cerevisiae Proteins Transcription Factors Tsg101 protein VPS4 protein, S cerevisiae Adenosine Triphosphatases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Perez O D

Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA 94305, USA.

Nolan G P

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1074-7613

DOI

10.1016/s1074-7613(01)00238-2

Published

2001-11-00

Pages

687-90

Language

English

Region

United States

NLM ID

9432918

Subset

External Links

PubMed source DOI: 10.1016/s1074-7613(01)00238-2 View journal details

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