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PMID: 11733550 Published · ppublish English Journal Article Comment

A kinase in the life of the beta cell.

The Journal of clinical investigation ·Vol. 108 ·No. 11 ·2001-12-00 ·Pages 1575-6

Accili D

Abstract

暂无摘要

MeSH Terms
Animals Cell Division Hypertrophy Insulin/metabolism Insulin Secretion Islets of Langerhans/pathology Mice Protein Serine-Threonine Kinases/physiology Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt
Chemicals
Insulin Proto-Oncogene Proteins Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Accili D
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. [email protected]
References (19)
19 references, click to expand
  1. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
    J Clin Invest. 1999 Dec;104(12):R69-75 PMID: 10606633
  2. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
    Cell. 1999 Feb 5;96(3):329-39 PMID: 10025399
  3. IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
    J Mol Endocrinol. 2000 Jun;24(3):303-11 PMID: 10828823
  4. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
    Diabetes. 2000 Nov;49(11):1880-9 PMID: 11078455
  5. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.
    Nature. 2000 Dec 21-28;408(6815):994-7 PMID: 11140689
  6. Intercellular signals regulating pancreas development and function.
    Genes Dev. 2001 Jan 15;15(2):111-27 PMID: 11157769
  7. Life and death of the pancreatic beta cells.
    Trends Endocrinol Metab. 2000 Nov;11(9):375-8 PMID: 11042468
  8. Association between islets of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together?
    Diabetologia. 2001 May;44(5):575-84 PMID: 11380075
  9. Evidence for a circulating islet cell growth factor in insulin-resistant states.
    Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7475-80 PMID: 11404474
  10. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.
    Mol Cell. 2001 Jun;7(6):1153-63 PMID: 11430819
  11. Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
    Mol Cell. 2001 Jun;7(6):1165-76 PMID: 11430820
  12. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells.
    Mol Cell. 2001 Mar;7(3):559-70 PMID: 11463381
  13. Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.
    Biochemistry. 2001 Oct 2;40(39):11768-76 PMID: 11570877
  14. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
    Nat Med. 2001 Oct;7(10):1133-7 PMID: 11590437
  15. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.
    J Clin Invest. 2001 Dec;108(11):1631-8 PMID: 11733558
  16. Characterization of immunoreactive components of insulin and somatostatin in canine pancreatic juice.
    FEBS Lett. 1979 Sep 1;105(1):23-6 PMID: 488343
  17. Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.
    Diabetes. 1996 Feb;45(2):223-41 PMID: 8549869
  18. Disruption of IRS-2 causes type 2 diabetes in mice.
    Nature. 1998 Feb 26;391(6670):900-4 PMID: 9495343
  19. Beta cell proliferation and growth factors.
    J Mol Med (Berl). 1999 Jan;77(1):62-6 PMID: 9930929
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
2001-12-00
Pages
1575-6
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC200994
Subset
IM
Corrections
CommentOn
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