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PMID: 11742077 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury.

Sun Y, Jin K, Mao XO, Zhu Y, Greenberg DA

Abstract

Globins are oxygen-binding heme proteins present in bacteria, protists, fungi, plants, and animals. Their functions have diverged widely in evolution, and include binding, transport, scavenging, detoxification, and sensing of gases like oxygen, nitric oxide, and carbon monoxide. Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen and preferential localization to vertebrate brain. No function for Ngb is known, but its affinity for oxygen and its expression in cerebral neurons suggest a role in neuronal responses to hypoxia or ischemia. Here we report that Ngb expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and that neuronal survival after hypoxia is reduced by inhibiting Ngb expression with an antisense oligodeoxynucleotide and enhanced by Ngb overexpression. Both induction of Ngb and its protective effect show specificity for hypoxia over other stressors. We conclude that hypoxia-inducible Ngb expression helps promote neuronal survival from hypoxic-ischemic insults.

MeSH Terms
Animals Base Sequence Brain/cytology,embryology DNA Primers Globins/genetics,metabolism,physiology Hypoxia-Ischemia, Brain/prevention & control Immunohistochemistry Mice Nerve Tissue Proteins/genetics,metabolism,physiology Neuroglobin Neurons/physiology Up-Regulation
Chemicals
DNA Primers Nerve Tissue Proteins Neuroglobin Globins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sun Y
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Jin K
Mao X O
Zhu Y
Greenberg D A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2001-12-18
Epub
2001-00-11
Pages
15306-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC65025
Subset
IM
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