A receptor for the third component of complement in the human renal glomerulus.

The Journal of experimental medicine ·Vol. 142 ·No. 4 ·1975-10-01 ·Pages 1029-34

Gelfand MC, Frank MM, Green I

Abstract

In the course of studying the nature of mononuclear cellular infiltrates in tissue sections of human kidney it was noted that indicator sheep erythrocytes densely coated with the third component of complement (C3) specifically adhered to all of the glomeruli in the tissue sections. The deposition of complement (C) within the glomerulus is a feature of many immunologically related renal diseases (1,2), yet the precise mechanism by which C is deposited remains unexplained. We feel that this observation, suggesting the presence of a receptor for C, is, therefore, of particular interest.

MeSH Terms

Animals Antigen-Antibody Complex Binding Sites, Antibody Complement C3 Complement System Proteins Erythrocytes/immunology Guinea Pigs Humans In Vitro Techniques Kidney Glomerulus/immunology Sheep

Chemicals

Antigen-Antibody Complex Complement C3 Complement System Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gelfand M C

Frank M M

Green I

References (7)

7 references, click to expand

C3b inactivator of man. II. Fragments produced by C3b inactivator cleavage of cell-bound or fluid phase C3b.
J Immunol. 1971 Sep;107(3):742-50 PMID: 4999095
Selected topics on immunological aspects of renal disease. Introduction.
Kidney Int. 1973 Feb;3(2):55-6 PMID: 4735169
Antigenic determinants of human beta-1c and beta-1g-globulins.
J Immunol. 1966 Apr;96(4):650-8 PMID: 4160740
Complement dependent immune phagocytosis. I. Requirements for C'1, C'4, C'2, C'3.
Exp Cell Res. 1968 Jul;51(1):45-67 PMID: 5661952
Nodular lymphoma--evidence for origin from follicular B lymphocytes.
N Engl J Med. 1974 Apr 11;290(15):813-9 PMID: 4544736
The effect of temperature on the reactivity of guinea-pig complement with gamma G and gamma M haemolytic antibodies.
Immunology. 1970 Dec;19(6):967-74 PMID: 5487543
Receptors for complement and immunoglobulin on human and animal lymphoid cells.
Transplant Rev. 1973;16:3-28 PMID: 4590768

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.142.4.1029

Published

1975-10-01

Pages

1029-34

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2189942

Subset

External Links

PubMed source DOI: 10.1084/jem.142.4.1029 PMC Full Text View journal details

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A receptor for the third component of complement in the human renal glomerulus.

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