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PMID: 1177092 Published · ppublish English Journal Article

Calcium and sodium ions as charge carriers in the action potential of an identified snail neurone.

The Journal of physiology ·Vol. 249 ·No. 2 ·1975-07-00 ·Pages 241-52

Standen NB

Abstract

1. The soma of cell A in Helix aspersa produced action potentials in sodium-free or calcium-free saline, but not in saline with neither sodium nor calcium. 2. The axon had a sodium-dependent action potential. 3. Tetrodotoxin (5 x 10(-6) M) had no effect on the overshoot except at low external divalent ion concentrations. 4. The action potential in sodium-free saline was blocked by cobalt. 5. The slope of action potential overshoot against sodium concentration in the presence of 10 mM calcium was 10.5 mV/tenfold change. That of overshoot against calcium concentration in the presence of 75 mM sodium was 22 mV/tenfold change. 6. In sodium-free saline the slope of overshoot versus calcium concentration was 27 mV/tenfold change. 7. It is concluded that calcium is an important charge carrier in the action potential of cell A.

MeSH Terms
Action Potentials/drug effects Animals Axons/physiology Calcium/metabolism,pharmacology Cobalt/pharmacology Helix, Snails In Vitro Techniques Neurons/physiology Sodium/metabolism,pharmacology Tetrodotoxin/pharmacology
Chemicals
Cobalt Tetrodotoxin Sodium Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Standen N B
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23 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1975.sp011013
Published
1975-07-00
Pages
241-52
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1309572
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1975.sp011013 PMC Full Text View journal details
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