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PMID: 11796577 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.

Infection and immunity ·Vol. 70 ·No. 2 ·2002-02-00 ·Pages 512-6

Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, Kimura M, Aikawa M

Abstract

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F(2) intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

MeSH Terms
Animals Chromosome Mapping Chromosomes Disease Models, Animal Female Genetic Predisposition to Disease/genetics Genotype Immunity, Innate/genetics Malaria, Cerebral/genetics,immunology Male Mice Mice, Inbred C57BL Mice, Inbred DBA Phenotype Plasmodium berghei/immunology
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Nagayasu Eiji
Institute of Science and Technology. Division of Molecular Life Science, School of Medicine. Division of Infectious Diseases, Tokai University, Isehara 259-1193, Japan.
Nagakura Koichi
Akaki Mayumi
Tamiya Gen
Makino Satoshi
Nakano Yamaji
Kimura Minoru
Aikawa Masamichi
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.70.2.512-516.2002
Published
2002-02-00
Pages
512-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC127666
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.70.2.512-516.2002 PMC Full Text View journal details
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