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PMID: 11805340 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Experience-dependent changes in cerebellar contributions to motor sequence learning.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 2 ·2002-01-22 ·Pages 1017-22

Doyon J, Song AW, Karni A, Lalonde F, Adams MM, Ungerleider LG

Abstract

Studies in experimental animals and humans have stressed the role of the cerebellum in motor skill learning. Yet, the relative importance of the cerebellar cortex and deep nuclei, as well as the nature of the dynamic functional changes occurring between these and other motor-related structures during learning, remains in dispute. Using functional magnetic resonance imaging and a motor sequence learning paradigm in humans, we found evidence of an experience-dependent shift of activation from the cerebellar cortex to the dentate nucleus during early learning, and from a cerebellar-cortical to a striatal-cortical network with extended practice. The results indicate that intrinsic modulation within the cerebellum, in concert with activation of motor-related cortical regions, serves to set up a procedurally acquired sequence of movements that is then maintained elsewhere in the brain.

MeSH Terms
Adult Animals Cerebellar Cortex/anatomy & histology,physiology Cerebellum/anatomy & histology,physiology Female Humans Learning/physiology Magnetic Resonance Imaging Male Models, Neurological Motor Neurons/physiology Motor Skills/physiology Neuronal Plasticity Reaction Time/physiology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Doyon Julien
Department of Psychology, University of Montreal, Montreal, QC, Canada H3C 3J7. [email protected]
Song Allen W
Karni Avi
Lalonde Francois
Adams Michelle M
Ungerleider Leslie G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.022615199
Email
[email protected]
Published
2002-01-22
Pages
1017-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC117423
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.022615199 PMC Full Text View journal details
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