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PMID: 118223 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of the immune response to hen's egg-white lysozyme in mice. I. Antibody and T-lymphocyte proliferative responses to the native protein.

Journal of immunogenetics ·Vol. 6 ·No. 6 ·1979-12-00 ·Pages 447-52

Okuda K, Sakata S, Atassi MZ, David CS

Abstract

We have initiated studies to determine whether the antibody and T-lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H-2f, H-2k and H-2p were high responders, while haplotypes H-2b, H-2d, H-2r and H-2s were low responders. Studies with recombinants indicated that the immune response is controlled by two H-2I region loci, one being in the I-A subregion and the other may be in the I-C subregions.

MeSH Terms

Animals Antibody Formation Cell Division Chickens Genes, MHC Class II H-2 Antigens/genetics Haploidy Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Muramidase/immunology Ovalbumin/immunology Recombination, Genetic T-Lymphocytes/cytology

Chemicals

H-2 Antigens Ovalbumin Muramidase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Okuda K

Sakata S

Atassi M Z

David C S

Article Info

Journal

Journal of immunogenetics

Abbr.

J Immunogenet

ISSN

0305-1811

DOI

10.1111/j.1744-313x.1979.tb00699.x

Published

1979-12-00

Pages

447-52

Language

English

Region

England

NLM ID

0425125

Subset

External Links

PubMed source DOI: 10.1111/j.1744-313x.1979.tb00699.x

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Genetic control of the immune response to hen's egg-white lysozyme in mice. I. Antibody and T-lymphocyte proliferative responses to the native protein.

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