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PMID: 11826118 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 22 ·No. 3 ·2002-02-01 ·Pages 886-900

Laurent A, Goaillard JM, Cases O, Lebrand C, Gaspar P, Ropert N

Abstract

The disruptive effect of excessive serotonin (5-HT) levels on the development of cortical sensory maps is mediated by 5-HT1B receptors, as shown in barrelless monoamine oxidase A knock-out mice, in which the additional inactivation of 5-HT1B receptors restores the barrels. However, it is unclear whether 5-HT1B receptors mediate their effect on barrel formation by a trophic action or an activity-dependent effect. To test for a possible effect of 5-HT1B receptors on activity, we studied the influence of 5-HT on the thalamocortical (TC) synaptic transmission in layer IV cortical neurons. In TC slices of postnatal day 5 (P5)-P9 neonate mice, we show that 5-HT reduces monosynaptic TC EPSCs evoked by low-frequency internal capsule stimulation and relieves the short-term depression of the EPSC evoked by high-frequency stimulation. We provide evidence that 5-HT decreases the presynaptic release of glutamate: 5-HT reduces similarly the AMPA-kainate and NMDA components and the paired pulse depression of TC EPSCs. We show also that 5-HT1B receptors mediate exclusively the effect of 5-HT: first, the effect of 5-HT on the TC EPSC is correlated with the transient expression of 5-HT1B receptor mRNAs in the ventrobasal thalamic nucleus during postnatal development; second, it is mimicked by a 5-HT1B agonist; third, 5-HT has no effect in 5-HT1B receptor knock-out mice. Our results show that in the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity.

MeSH Terms
Aging/metabolism Animals Animals, Newborn Electric Stimulation Excitatory Postsynaptic Potentials/drug effects,physiology In Vitro Techniques Mice Mice, Inbred Strains Mice, Knockout Neural Inhibition/drug effects Neurons/drug effects,metabolism Patch-Clamp Techniques Presynaptic Terminals/drug effects,metabolism Pyridines/pharmacology Pyrroles/pharmacology RNA, Messenger/metabolism Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin/deficiency,genetics,metabolism Serotonin/pharmacology Serotonin Receptor Agonists/pharmacology Somatosensory Cortex/drug effects,physiology Synaptic Transmission/drug effects,physiology Thalamus/drug effects,growth & development,physiology Ventral Thalamic Nuclei/growth & development,metabolism
Chemicals
Pyridines Pyrroles RNA, Messenger Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin Serotonin Receptor Agonists 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one Serotonin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Laurent Alban
Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale (INSERM) EPI-0002, Ecole Supérieure de Physique et de Chimie Industrielle, 75231 Paris cedex 5, France,
Goaillard Jean-Marc
Cases Olivier
Lebrand Cecile
Gaspar Patricia
Ropert Nicole
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2002-02-01
Pages
886-900
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6758531
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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