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PMID: 11834378 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.

Current opinion in microbiology ·Vol. 5 ·No. 1 ·2002-02-00 ·Pages 102-10

Tzou P, De Gregorio E, Lemaitre B

Abstract

During the past year, dramatic progress has been achieved in our understanding of Drosophila immune reactions. The completion of the Drosophila genome sequencing project, microarray analysis and the use of genetic screens have led to the identification of several new genes required to combat microbial infection, filling in some important gaps in the understanding of innate immunity. At the same time, this insect was used as a model for the study of host-pathogen interactions. The recent major advances on the mechanisms by which this insect defends itself against intrusion of pathogens are discussed in this review.

MeSH Terms
Animals Antibody Formation/genetics Antigens, Bacterial/blood Antimicrobial Cationic Peptides/immunology,physiology Bacterial Infections/immunology,prevention & control Blood Coagulation/immunology Cell Differentiation DNA-Binding Proteins/immunology,pharmacology Drosophila/anatomy & histology,immunology Drosophila Proteins/immunology,pharmacology Fat Body/immunology Hemocytes/physiology Host-Parasite Interactions Immunity, Cellular/genetics Immunity, Innate Janus Kinase 1 Melanins/biosynthesis,immunology Membrane Glycoproteins/immunology,pharmacology Models, Biological Protein-Tyrosine Kinases/immunology,pharmacology Receptors, Cell Surface STAT Transcription Factors Signal Transduction Toll-Like Receptors Trans-Activators/immunology,pharmacology
Chemicals
Antigens, Bacterial Antimicrobial Cationic Peptides DNA-Binding Proteins Drosophila Proteins Melanins Membrane Glycoproteins Receptors, Cell Surface STAT Transcription Factors Stat92E protein, Drosophila Tl protein, Drosophila Toll-Like Receptors Trans-Activators imd protein, Drosophila Protein-Tyrosine Kinases Janus Kinase 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tzou Phoebe
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France.
De Gregorio Ennio
Lemaitre Bruno
Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1369-5274
DOI
10.1016/s1369-5274(02)00294-1
Published
2002-02-00
Pages
102-10
Language
English
Region
England
NLM ID
9815056
Subset
IM
External Links
PubMed source DOI: 10.1016/s1369-5274(02)00294-1 View journal details
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