Home LiteratureArticle Details
PMID: 11835605 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Modeling of activation data in the BrainMap database: detection of outliers.

Human brain mapping ·Vol. 15 ·No. 3 ·2002-03-00 ·Pages 146-56

Nielsen FA, Hansen LK

Abstract

We describe a system for meta-analytical modeling of activation foci from functional neuroimaging studies. Our main vehicle is a set of density models in Talairach space capturing the distribution of activation foci in sets of experiments labeled by lobar anatomy. One important use of such density models is identification of novelty, i.e., low probability database events. We rank the novelty of the outliers and investigate the cause for 21 of the most novel, finding several outliers that are entry and transcription errors or infrequent or non-conforming terminology. We briefly discuss the use of atlases for outlier detection.

MeSH Terms
Brain Mapping/methods Databases, Factual/statistics & numerical data Meta-Analysis as Topic Models, Neurological Probability Theory
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nielsen Finn Arup
Informatics and Mathematical Modelling, Building 321, Technical University of Denmark, DK-8200 Lyngby, Denmark. [email protected]
Hansen Lars Kai
References (32)
32 references, click to expand
  1. A PET study of visuospatial attention.
    J Neurosci. 1993 Mar;13(3):1202-26 PMID: 8441008
  2. Social perception from visual cues: role of the STS region.
    Trends Cogn Sci. 2000 Jul;4(7):267-278 PMID: 10859571
  3. Beyond the single study: function/location metanalysis in cognitive neuroimaging.
    Curr Opin Neurobiol. 1998 Apr;8(2):178-87 PMID: 9635200
  4. Vocal identification of speaker and emotion activates different brain regions.
    Neuroreport. 1997 Aug 18;8(12):2809-12 PMID: 9295122
  5. Alexia for Braille following bilateral occipital stroke in an early blind woman.
    Neuroreport. 2000 Feb 7;11(2):237-40 PMID: 10674462
  6. Neural tree density estimation for novelty detection.
    IEEE Trans Neural Netw. 1998;9(2):330-8 PMID: 18252456
  7. The critical relationship between the timing of stimulus presentation and data acquisition in blocked designs with fMRI.
    Neuroimage. 1999 Jul;10(1):36-44 PMID: 10385579
  8. Functional volumes modeling: scaling for group size in averaged images.
    Hum Brain Mapp. 1999;8(2-3):143-50 PMID: 10524606
  9. Imaging visual recognition: PET and fMRI studies of the functional anatomy of human visual recognition.
    Trends Cogn Sci. 1999 May;3(5):179-186 PMID: 10322474
  10. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study.
    Ann Neurol. 1994 Oct;36(4):636-42 PMID: 7944296
  11. A symbolic environment for visualizing activated foci in functional neuroimaging datasets.
    Med Image Anal. 1998 Sep;2(3):215-26 PMID: 9873900
  12. Positron emission tomographic studies of the cortical anatomy of single-word processing.
    Nature. 1988 Feb 18;331(6157):585-9 PMID: 3277066
  13. Functional volumes modeling: theory and preliminary assessment.
    Hum Brain Mapp. 1997;5(4):306-11 PMID: 20408233
  14. Language localization with activation positron emission tomography scanning.
    Neurosurgery. 1992 Aug;31(2):369-73 PMID: 1513446
  15. Identifying objects seen from different viewpoints. A PET investigation.
    Brain. 1994 Oct;117 ( Pt 5):1055-71 PMID: 7953588
  16. Neuroscience on the net.
    Science. 1994 Nov 11;266(5187):994-6 PMID: 7973682
  17. Functional anatomic studies of memory retrieval for auditory words and visual pictures.
    J Neurosci. 1996 Oct 1;16(19):6219-35 PMID: 8815903
  18. Within-arm somatotopy in human motor areas determined by positron emission tomography imaging of cerebral blood flow.
    Exp Brain Res. 1993;95(1):172-6 PMID: 8405250
  19. Localization of a human system for sustained attention by positron emission tomography.
    Nature. 1991 Jan 3;349(6304):61-4 PMID: 1985266
  20. Neuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition.
    Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2012-5 PMID: 8134341
  21. Functional neuroanatomy of verbal free recall: A replication study.
    Hum Brain Mapp. 1994;1(4):284-92 PMID: 24591197
  22. Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method.
    Hum Brain Mapp. 1997;5(4):238-42 PMID: 20408222
  23. Functional magnetic resonance imaging of human brain activity in a verbal fluency task.
    J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):492-8 PMID: 9576541
  24. The cortical localization of the lexicons. Positron emission tomography evidence.
    Brain. 1992 Dec;115 ( Pt 6):1769-82 PMID: 1486460
  25. Neural mechanisms subserving the perception of human actions.
    Trends Cogn Sci. 1999 May;3(5):172-178 PMID: 10322473
  26. A PET study of somatosensory discrimination in man. microgeometry versus macrogeometry.
    Eur J Neurosci. 1994 Jan 1;6(1):137-48 PMID: 8130929
  27. Involvement of visual cortex in tactile discrimination of orientation.
    Nature. 1999 Oct 7;401(6753):587-90 PMID: 10524625
  28. Memory for object features versus memory for object location: a positron-emission tomography study of encoding and retrieval processes.
    Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9212-7 PMID: 8799180
  29. Imaging cognition II: An empirical review of 275 PET and fMRI studies.
    J Cogn Neurosci. 2000 Jan;12(1):1-47 PMID: 10769304
  30. Lateralized automatic auditory processing of phonetic versus musical information: a PET study.
    Hum Brain Mapp. 2000 Jun;10(2):74-9 PMID: 10864231
  31. Location-probability profiles for the mouth region of human primary motor-sensory cortex: model and validation.
    Neuroimage. 2001 Jan;13(1):196-209 PMID: 11133322
  32. Location and function of the human frontal eye-field: a selective review.
    Neuropsychologia. 1996 Jun;34(6):475-83 PMID: 8736560
Article Info
Journal
Human brain mapping
Abbr.
Hum Brain Mapp
ISSN
1065-9471
DOI
10.1002/hbm.10012
Email
[email protected]
Published
2002-03-00
Pages
146-56
Language
English
Region
United States
NLM ID
9419065
PMCID
PMC6871805
Subset
IM
Grants
NIMH NIH HHS · P20 MH057180 · United States
NIMH NIH HHS · P20 MH 57180 · United States
NIDA NIH HHS · R01 DA 09246 · United States
External Links
PubMed source DOI: 10.1002/hbm.10012 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2