Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.

Bioorganic & medicinal chemistry letters ·Vol. 12 ·No. 4 ·2002-02-25 ·页码 571-4

Wang S, Ryder H, Pretswell I, Depledge P, Milton J, Hancox TC, Dale I, Dangerfield W, Charlton P, Faint R, Dodd R, Hassan S

Abstract

The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.

MeSH 主题词

ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors Antibiotics, Antineoplastic/antagonists & inhibitors,pharmacokinetics Antineoplastic Agents/antagonists & inhibitors,pharmacokinetics Daunorubicin/antagonists & inhibitors,pharmacokinetics Doxorubicin/antagonists & inhibitors,pharmacokinetics Drug Interactions Drug Resistance, Multiple Humans Inhibitory Concentration 50 Quinazolines/chemical synthesis,chemistry,pharmacology Structure-Activity Relationship Tumor Cells, Cultured

化学物质

ATP Binding Cassette Transporter, Subfamily B, Member 1 Antibiotics, Antineoplastic Antineoplastic Agents Quinazolines Doxorubicin Daunorubicin

作者与单位

共 12 位作者，点击展开单位 / ORCID

Wang Shouming

Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK. [email protected]

Ryder Hamish

Pretswell Ian

Depledge Paul

Milton John

Hancox Timothy C

Dale Ian

Dangerfield Wendy

Charlton Peter

Faint Richard

Dodd Rory

Hassan Stephanie

Article Info

Journal

Bioorganic & medicinal chemistry letters

Abbr.

Bioorg Med Chem Lett

ISSN

0960-894X

DOI

10.1016/s0960-894x(01)00804-6

Corresponding email

[email protected]

Published

2002-02-25

页码

571-4

Language

English

Country/Region

England

NLM ID

9107377

External Links

PubMed source DOI: 10.1016/s0960-894x(01)00804-6 View journal details

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Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.

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