Home LiteratureArticle Details

PMID: 1186855 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins.

Nature ·Vol. 257 ·No. 5529 ·1975-10-30 ·Pages 764-7

Stein G, Park W, Thrall C, Mans R, Stein J

Abstract

RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.

MeSH Terms

Cell Division Cell-Free System Chromatin/metabolism Chromosomes/metabolism Deoxyribonucleoproteins/metabolism HeLa Cells Histones/biosynthesis Nucleoproteins/metabolism Transcription, Genetic

Chemicals

Chromatin Deoxyribonucleoproteins Histones Nucleoproteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Stein G

Park W

Thrall C

Mans R

Stein J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/257764a0

Published

1975-10-30

Pages

764-7

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/257764a0 View journal details

Analysis Services

Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins.

Contact

WeChat Official Account