Microbial minimalism: genome reduction in bacterial pathogens.

Cell ·Vol. 108 ·No. 5 ·2002-03-08 ·Pages 583-6

Moran NA

Abstract

When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts.

MeSH Terms

Bacteria/genetics,pathogenicity Base Composition Biological Evolution Databases, Genetic Genes, Bacterial Genome, Bacterial Mutation Open Reading Frames

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Moran Nancy A

Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA. [email protected]

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)00665-7

[email protected]

Published

2002-03-08

Pages

583-6

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/s0092-8674(02)00665-7 View journal details

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