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PMID: 11900251 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Putting tumours in context.

Nature reviews. Cancer ·Vol. 1 ·No. 1 ·2001-10-00 ·Pages 46-54

Bissell MJ, Radisky D

Abstract

The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.

MeSH Terms
Animals Humans Matrix Metalloproteinases/physiology Neoplasms/etiology,immunology,therapy Stromal Cells/physiology Wound Healing
Chemicals
Matrix Metalloproteinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bissell M J
Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 99720, USA. [email protected]
Radisky D
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-175X
DOI
10.1038/35094059
Email
[email protected]
Published
2001-10-00
Pages
46-54
Language
English
Region
England
NLM ID
101124168
PMCID
PMC2975572
Subset
IM
Grants
NCI NIH HHS · U01 CA143233-01 · United States
NCI NIH HHS · U54 CA143836 · United States
NCI NIH HHS · U54 CA112970-01 · United States
NCI NIH HHS · R01 CA064786-05 · United States
NCI NIH HHS · U54 CA126552 · United States
NCI NIH HHS · U54 CA143836-01 · United States
NCI NIH HHS · R01 CA057621-11 · United States
NCI NIH HHS · U54 CA112970 · United States
NCI NIH HHS · U54 CA126552-01 · United States
NCI NIH HHS · R01 CA057621 · United States
NCI NIH HHS · U01 CA143233 · United States
NCI NIH HHS · R01 CA064786 · United States
External Links
PubMed source DOI: 10.1038/35094059 PMC Full Text View journal details
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