Multidrug resistance in cancer: role of ATP-dependent transporters.

Nature reviews. Cancer ·Vol. 2 ·No. 1 ·2002-01-00 ·Pages 48-58

Gottesman MM, Fojo T, Bates SE

Abstract

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy.

MeSH Terms

ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors,genetics,physiology ATP-Binding Cassette Transporters/physiology Adenosine Triphosphate/metabolism Antineoplastic Agents/pharmacokinetics Biomarkers Breast Neoplasms/metabolism Drug Design Drug Resistance, Multiple Drug Resistance, Neoplasm Female Forecasting Humans Leukemia/metabolism Multidrug Resistance-Associated Proteins/chemistry,classification,genetics,physiology Multigene Family Neoplasm Proteins/physiology Neoplasms/drug therapy,metabolism Organ Specificity Permeability Structure-Activity Relationship Xenobiotics/adverse effects,pharmacokinetics

Chemicals

ATP Binding Cassette Transporter, Subfamily B, Member 1 ATP-Binding Cassette Transporters Antineoplastic Agents Biomarkers Multidrug Resistance-Associated Proteins Neoplasm Proteins Xenobiotics Adenosine Triphosphate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gottesman Michael M

Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA. [email protected]

Fojo Tito

Bates Susan E

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/nrc706

[email protected]

Published

2002-01-00

Pages

48-58

Language

English

Region

England

NLM ID

101124168

Subset

External Links

PubMed source DOI: 10.1038/nrc706 View journal details

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Multidrug resistance in cancer: role of ATP-dependent transporters.

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