Fluid and penicillin G dynamics in polyethylene chambers implanted subcutaneously in rabbits.

Antimicrobial agents and chemotherapy ·Vol. 8 ·No. 4 ·1975-10-00 ·Pages 495-7

Tight RR, Prior RB, Perkins RL, Rotilie CA

Abstract

Chemical and cellular characteristics of fluid within subcutaneously implanted polyethylene chambers in rabbits were studied over a 3-month period. The fluid attained a relatively stable protein and cellular composition which was consistent with a mononuclear exudate. After a single dose of intramuscular penicillin G, the antibacterial activity of chamber fluid was found to be dynamic and similar to the serum antibacterial activity. This animal model may be useful for in vivo studies of the interaction of microorganisms with antimicrobial agents.

MeSH Terms

Animals Drug Implants Female Injections, Subcutaneous Male Penicillin G/administration & dosage,metabolism Polyethylenes Rabbits Time Factors

Chemicals

Drug Implants Polyethylenes Penicillin G

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tight R R

Prior R B

Perkins R L

Rotilie C A

References (6)

6 references, click to expand

[Experimental body cavities in rabbits for the analysis of possible bacterial virulence factors (author's transl)].
Zentralbl Bakteriol Orig A. 1974 Dec;229(4):503-10 PMID: 4155902
Implantation and use of a subcutaneous culture chamber in laboratory animals.
Lab Anim Sci. 1973 Feb;23(1):105-6 PMID: 4347748
Neisseria gonorrhoeae: experimental infection of laboratory animals.
Science. 1972 Sep 29;177(4055):1200-1 PMID: 4626945
Cultivation of pathogenic Treponema pallidum in chambers surgically implanted in experimental animals.
Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Apr;81(2):269-71 PMID: 4588431
Fluid and pharmacological dynamics in a subcutaneous chamber implanted in rats.
Antimicrob Agents Chemother. 1973 Aug;4(2):196-7 PMID: 4790940
Concentration of antibacterial agents in interstitial tissue fluid.
Br Med J. 1973 Mar 10;1(5853):569-73 PMID: 4694402

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.8.4.495

Published

1975-10-00

Pages

495-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429380

Subset

External Links

PubMed source DOI: 10.1128/AAC.8.4.495 PMC Full Text View journal details

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Fluid and penicillin G dynamics in polyethylene chambers implanted subcutaneously in rabbits.

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