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PMID: 11909523 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

A conserved mRNA export machinery coupled to pre-mRNA splicing.

Cell ·Vol. 108 ·No. 4 ·2002-02-22 ·Pages 523-31

Reed R, Hurt E

Abstract

Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

MeSH Terms

Active Transport, Cell Nucleus/physiology Animals Fungal Proteins/metabolism Heterogeneous-Nuclear Ribonucleoproteins Humans Models, Biological Nuclear Proteins/metabolism RNA Precursors/metabolism RNA Splicing RNA, Messenger/metabolism RNA-Binding Proteins/metabolism Ribonucleoproteins/metabolism Spliceosomes/metabolism

Chemicals

Fungal Proteins Heterogeneous-Nuclear Ribonucleoproteins Nuclear Proteins RNA Precursors RNA, Messenger RNA-Binding Proteins Ribonucleoproteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Reed Robin

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. [email protected]

Hurt Ed

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)00627-x

[email protected]

Published

2002-02-22

Pages

523-31

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/s0092-8674(02)00627-x View journal details

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A conserved mRNA export machinery coupled to pre-mRNA splicing.

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