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PMID: 11918686 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Diversity in MHC class II antigen presentation.

Immunology ·Vol. 105 ·No. 3 ·2002-03-00 ·Pages 252-62

Robinson JH, Delvig AA

Abstract

Processing exogenous and endogenous proteins for presentation by major histocompatibility complex (MHC) molecules to T cells is the defining function of antigen-presenting cells (APC) as major regulatory cells in the acquired immune response. MHC class II-restricted antigen presentation to CD4 T cells is achieved by an essentially common pathway that is subject to variation with regard to the location and extent of degradation of protein antigens and the site of peptide binding to MHC class II molecules. These subtle variations reveal a surprising flexibility in the ways a diverse peptide repertoire is displayed on the APC surface. This diversity may have profound consequences for the induction of immunity to infection and tumours, as well as autoimmunity and tolerance.

MeSH Terms
Animals Antigen Presentation Autoimmunity Endosomes/immunology Histocompatibility Antigens Class II/immunology Humans Infections/immunology Neoplasms/immunology Phagosomes/immunology T-Lymphocyte Subsets/immunology
Chemicals
Histocompatibility Antigens Class II
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Robinson John H
Department of Microbiology and Immunology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. [email protected]
Delvig Alexei A
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1046/j.0019-2805.2001.01358.x
Email
[email protected]
Published
2002-03-00
Pages
252-62
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1782669
Subset
IM
External Links
PubMed source DOI: 10.1046/j.0019-2805.2001.01358.x PMC Full Text View journal details
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