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PMID: 1193685 Published · ppublish English Journal Article

Investigation of the binding site of mouse IgG subclasses to homologous peritoneal macrophages.

Immunology ·Vol. 29 ·No. 6 ·1975-12-00 ·Pages 1111-8

Dissanayake S, Hay FC

Abstract

The binding of mouse myeloma IgG1, IgG2a, IgG2b, IgG1 Fc, IgG2b Fc and a pepsin produced C-terminal subfragment of IgG1 Fc and IgG2b Fc (provisionally identified as pFc') to mouse peritoneal macrophages was investigated. The high affinity cytophilic antibodies belonged to IgG2 subclasses and the binding site of these antibodies was located in the CH3 homology region.

MeSH Terms
Animals Antibodies Ascitic Fluid/cytology Binding Sites, Antibody Immune Adherence Reaction Immunity, Cellular Immunoglobulin Fc Fragments Immunoglobulin G Iodine Radioisotopes Macrophages/immunology Mice Myeloma Proteins
Chemicals
Antibodies Immunoglobulin Fc Fragments Immunoglobulin G Iodine Radioisotopes Myeloma Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dissanayake S
Hay F C
References (23)
23 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1975-12-00
Pages
1111-8
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1446024
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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