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PMID: 11951031 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Decoding the patterns of self and nonself by the innate immune system.

Science (New York, N.Y.) ·Vol. 296 ·No. 5566 ·2002-04-12 ·Pages 298-300

Medzhitov R, Janeway CA

Abstract

The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.

MeSH Terms

Animals Antigens, CD/immunology Apoptosis Biological Evolution Complement Pathway, Alternative Histocompatibility Antigens Class I/immunology Humans Immunity, Innate Inflammation Killer Cells, Natural/immunology Lipopolysaccharides/immunology Necrosis Peptidoglycan/immunology Receptors, Immunologic/immunology Self Tolerance Sialic Acids/metabolism

Chemicals

Antigens, CD Histocompatibility Antigens Class I Lipopolysaccharides Peptidoglycan Receptors, Immunologic Sialic Acids

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Medzhitov Ruslan

Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. [email protected]

Janeway Charles A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1068883

[email protected]

Published

2002-04-12

Pages

298-300

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1068883 View journal details

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Decoding the patterns of self and nonself by the innate immune system.

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