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PMID: 11956233 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The cadherin-catenin adhesion system in signaling and cancer.

The Journal of clinical investigation ·Vol. 109 ·No. 8 ·2002-04-00 ·Pages 987-91

Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A

Abstract

暂无摘要

MeSH Terms
Adherens Junctions/physiology Animals Cadherins/genetics,physiology Cell Adhesion/physiology Cytoskeletal Proteins/physiology Humans Mutation Neoplasms/physiopathology Receptor Cross-Talk Receptors, Growth Factor/physiology Signal Transduction Trans-Activators Transcriptional Activation beta Catenin rho GTP-Binding Proteins/physiology
Chemicals
CTNNB1 protein, human Cadherins Cytoskeletal Proteins Receptors, Growth Factor Trans-Activators beta Catenin rho GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Conacci-Sorrell Maralice
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Zhurinsky Jacob
Ben-Ze'ev Avri
References (56)
56 references, click to expand
  1. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).
    J Cell Biol. 1998 Jul 27;142(2):557-71 PMID: 9679152
  2. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin.
    J Cell Biol. 1998 Jun 15;141(6):1433-48 PMID: 9628899
  3. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
    Am J Pathol. 1998 Aug;153(2):333-9 PMID: 9708792
  4. Identification of c-MYC as a target of the APC pathway.
    Science. 1998 Sep 4;281(5382):1509-12 PMID: 9727977
  5. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer.
    Curr Opin Cell Biol. 1998 Oct;10(5):629-39 PMID: 9818174
  6. Inhibition of beta-catenin-mediated transactivation by cadherin derivatives.
    Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15339-44 PMID: 9860970
  7. Cancer epigenetics comes of age.
    Nat Genet. 1999 Feb;21(2):163-7 PMID: 9988266
  8. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
    Nature. 1999 Apr 1;398(6726):422-6 PMID: 10201372
  9. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
    Proc Natl Acad Sci U S A. 1999 May 11;96(10):5522-7 PMID: 10318916
  10. Excess beta-catenin promotes accumulation of transcriptionally active p53.
    EMBO J. 1999 Jun 1;18(11):3054-63 PMID: 10357817
  11. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
    Oncogene. 1999 May 6;18(18):2883-91 PMID: 10362259
  12. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression.
    Mol Cell Biol. 1999 Aug;19(8):5576-87 PMID: 10409747
  13. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
    Nat Cell Biol. 2000 Feb;2(2):84-9 PMID: 10655587
  14. Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion.
    J Biol Chem. 2000 Feb 18;275(7):5090-5 PMID: 10671552
  15. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis.
    J Cell Biol. 2000 Feb 21;148(4):779-90 PMID: 10684258
  16. Wnt signaling and cancer.
    Genes Dev. 2000 Aug 1;14(15):1837-51 PMID: 10921899
  17. Plakoglobin and beta-catenin: protein interactions, regulation and biological roles.
    J Cell Sci. 2000 Sep;113 ( Pt 18):3127-39 PMID: 10954412
  18. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.
    Nat Genet. 2000 Sep;26(1):16-7 PMID: 10973239
  19. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis.
    Cancer Res. 2000 Sep 1;60(17):4761-6 PMID: 10987283
  20. Linking colorectal cancer to Wnt signaling.
    Cell. 2000 Oct 13;103(2):311-20 PMID: 11057903
  21. Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
    Cancer Res. 2001 Jan 1;61(1):278-84 PMID: 11196175
  22. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.
    Cell. 2001 Feb 23;104(4):605-17 PMID: 11239416
  23. Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells.
    Mol Biol Cell. 2001 Apr;12(4):1177-88 PMID: 11294915
  24. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner.
    J Cell Biol. 2001 May 28;153(5):1049-60 PMID: 11381089
  25. Regulation of beta-catenin structure and activity by tyrosine phosphorylation.
    J Biol Chem. 2001 Jun 8;276(23):20436-43 PMID: 11279024
  26. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
    Mol Cell. 2001 May;7(5):915-26 PMID: 11389839
  27. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
    Mol Cell. 2001 May;7(5):927-36 PMID: 11389840
  28. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
    Mol Cell. 2001 Jun;7(6):1267-78 PMID: 11430829
  29. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.
    J Biol Chem. 2001 Jul 20;276(29):27424-31 PMID: 11309385
  30. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
    J Cell Biol. 2001 Jul 23;154(2):369-87 PMID: 11470825
  31. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.
    Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10356-61 PMID: 11526241
  32. Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.
    EMBO J. 2001 Sep 3;20(17):4912-22 PMID: 11532955
  33. Molecular architecture of adherens junctions.
    Curr Opin Cell Biol. 2001 Oct;13(5):600-3 PMID: 11544029
  34. E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity.
    J Cell Biol. 2001 Sep 17;154(6):1185-96 PMID: 11564756
  35. Down-regulation of beta-catenin by activated p53.
    Mol Cell Biol. 2001 Oct;21(20):6768-81 PMID: 11564862
  36. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition.
    Bioessays. 2001 Oct;23(10):912-23 PMID: 11598958
  37. Rho family proteins: coordinating cell responses.
    Trends Cell Biol. 2001 Dec;11(12):471-7 PMID: 11719051
  38. Rho-family GTPases in cadherin-mediated cell-cell adhesion.
    Nat Rev Mol Cell Biol. 2001 Dec;2(12):887-97 PMID: 11733768
  39. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
    Cell. 1991 Jul 12;66(1):107-19 PMID: 2070412
  40. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
    Cell. 1992 Jul 24;70(2):293-301 PMID: 1638632
  41. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.
    Cell. 1994 Dec 2;79(5):791-803 PMID: 7528101
  42. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.
    J Cell Biol. 1995 Jul;130(2):461-71 PMID: 7542250
  43. Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.
    J Cell Biol. 1996 Mar;132(6):1105-14 PMID: 8601588
  44. An overview of epithelio-mesenchymal transformation.
    Acta Anat (Basel). 1995;154(1):8-20 PMID: 8714286
  45. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion.
    Exp Cell Res. 1996 Jul 10;226(1):214-22 PMID: 8660958
  46. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
    J Cell Biol. 1997 Jun 16;137(6):1421-31 PMID: 9182672
  47. Expression of wild-type alpha-catenin protein in cells with a mutant alpha-catenin gene restores both growth regulation and tumor suppressor activities.
    Mol Cell Biol. 1997 Aug;17(8):4501-8 PMID: 9234707
  48. Rho GTPases and signaling networks.
    Genes Dev. 1997 Sep 15;11(18):2295-322 PMID: 9308960
  49. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells.
    J Cell Biol. 1997 Nov 17;139(4):1047-59 PMID: 9362522
  50. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.
    Science. 1997 Nov 21;278(5342):1464-6 PMID: 9367959
  51. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression.
    J Cell Biol. 1999 Nov 1;147(3):631-44 PMID: 10545506
  52. Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.
    J Biol Chem. 1999 Dec 17;274(51):36734-40 PMID: 10593980
  53. Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.
    J Biol Chem. 2000 Jan 28;275(4):2727-32 PMID: 10644736
  54. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.
    Nat Cell Biol. 2000 Feb;2(2):76-83 PMID: 10655586
  55. A causal role for E-cadherin in the transition from adenoma to carcinoma.
    Nature. 1998 Mar 12;392(6672):190-3 PMID: 9515965
  56. Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly.
    Mol Biol Cell. 1998 Aug;9(8):2185-200 PMID: 9693375
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI15429
Published
2002-04-00
Pages
987-91
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC150951
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI15429 PMC Full Text View journal details
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