Tsg101: HIV-1's ticket to ride.

Trends in microbiology ·Vol. 10 ·No. 5 ·2002-05-00 ·Pages 203-5

Carter CA

Abstract

Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.

MeSH Terms

Adenosine Triphosphatases DNA-Binding Proteins/metabolism Endosomal Sorting Complexes Required for Transport Fungal Proteins/metabolism Gene Products, gag/chemistry,metabolism HIV-1/growth & development,metabolism Humans Protein Transport Saccharomyces cerevisiae Proteins Transcription Factors/metabolism Ubiquitin/metabolism Vacuoles/metabolism

Chemicals

DNA-Binding Proteins Endosomal Sorting Complexes Required for Transport Fungal Proteins Gene Products, gag Saccharomyces cerevisiae Proteins Transcription Factors Tsg101 protein Ubiquitin VPS4 protein, S cerevisiae Adenosine Triphosphatases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Carter Carol A

Department of Molecular Genetics & Microbiology, Life Sciences Bldg, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA. [email protected]

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/s0966-842x(02)02350-8

[email protected]

Published

2002-05-00

Pages

203-5

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/s0966-842x(02)02350-8 View journal details

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