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PMID: 11975517 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.

Journal of natural products ·Vol. 65 ·No. 4 ·2002-04-00 ·Pages 616-7

Hwang BY, Lee JH, Nam JB, Kim HS, Hong YS, Lee JJ

Abstract

Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) with an EC(50) value of 16.7 microM; however, saurufuran B (2), with an EC(50) value of >100 microM, weakly activated the PPARgamma.

MeSH Terms
3T3 Cells/drug effects Animals Cells, Cultured/drug effects Diterpenes/chemistry,isolation & purification,pharmacology Furans/chemistry,isolation & purification,pharmacology Humans Korea Ligands Luciferases/metabolism Mice Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots/chemistry Plants, Medicinal/chemistry Receptors, Cytoplasmic and Nuclear/agonists Transcription Factors/agonists Transfection beta-Galactosidase/metabolism
Chemicals
Diterpenes Furans Ligands Receptors, Cytoplasmic and Nuclear Transcription Factors saurufuran A saurufuran B Luciferases beta-Galactosidase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hwang Bang Yeon
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Lee Jeong-Hyung
Nam Jeong Bum
Kim Hang Sub
Hong Young Soo
Lee Jung Joon
Article Info
Journal
Journal of natural products
Abbr.
J Nat Prod
ISSN
0163-3864
DOI
10.1021/np010440j
Published
2002-04-00
Pages
616-7
Language
English
Region
United States
NLM ID
7906882
Subset
IM
External Links
PubMed source DOI: 10.1021/np010440j View journal details
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