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该文献已被撤稿（Retracted Publication），引用前请核实。
PMID: 11978815 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Retracted Publication

Hydrogen sulfide is produced in response to neuronal excitation.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 22 ·No. 9 ·2002-05-01 ·Pages 3386-91

Eto K, Ogasawara M, Umemura K, Nagai Y, Kimura H

Abstract

Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. This increased CBS activity is regulated by a pathway involving Ca2+/calmodulin. In addition, LTP is altered in CBS knock-out mice. These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.

MeSH Terms
Animals Binding Sites/physiology Brain Chemistry COS Cells Calcium/metabolism Calmodulin/antagonists & inhibitors,metabolism Cerebral Cortex/chemistry,metabolism Cystathionine beta-Synthase/chemistry,deficiency,genetics Cysteine/analysis Dose-Response Relationship, Drug Electric Stimulation Enzyme Inhibitors/pharmacology Glutamic Acid/metabolism,pharmacology Hydrogen Sulfide/analysis,metabolism In Vitro Techniques Ionophores/pharmacology Long-Term Potentiation/physiology Mice Mice, Knockout Neurons/cytology,drug effects,metabolism Precipitin Tests Protein Binding/physiology Signal Transduction/physiology Synaptic Transmission/physiology Transfection
Chemicals
Calmodulin Enzyme Inhibitors Ionophores Glutamic Acid Cystathionine beta-Synthase Cysteine Calcium Hydrogen Sulfide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Eto Ko
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.
Ogasawara Miki
Umemura Ken
Nagai Yasuo
Kimura Hideo
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
20026328
Published
2002-05-01
Pages
3386-91
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6758394
Subset
IM
Grants
NIGMS NIH HHS · 5R21GM57504 · United States
Corrections
RetractionIn
PMID: 15201338
External Links
PubMed source DOI: 20026328 PMC Full Text View journal details
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