Abstract
The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes and in different organisms. This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.
MeSH Terms
Animals
Carrier Proteins/metabolism
Cytokines/metabolism
DNA-Binding Proteins/chemistry,metabolism
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins
Janus Kinase 1
Methylation
Protein Inhibitors of Activated STAT
Protein-Tyrosine Kinases/metabolism
Proteins/metabolism
Receptors, Cytokine/metabolism
Repressor Proteins
STAT1 Transcription Factor
Signal Transduction
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins
Trans-Activators/chemistry,metabolism
Chemicals
Carrier Proteins
Cytokines
DNA-Binding Proteins
Intracellular Signaling Peptides and Proteins
Protein Inhibitors of Activated STAT
Proteins
Receptors, Cytokine
Repressor Proteins
SOCS1 protein, human
STAT1 Transcription Factor
STAT1 protein, human
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins
Trans-Activators
Protein-Tyrosine Kinases
JAK1 protein, human
Janus Kinase 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
O'Shea John J
Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA.
[email protected]
Gadina Massimo
Schreiber Robert D