Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Animals Brain/metabolism Caudate Nucleus/metabolism Cell Death Cell Line Cell Nucleus/metabolism Cells, Cultured Corpus Striatum/cytology,embryology,metabolism DNA/metabolism DNA-Binding Proteins/chemistry,metabolism Down-Regulation Gene Expression Regulation Humans Huntingtin Protein Huntington Disease/genetics,metabolism Mice Mice, Transgenic Mutation Nerve Tissue Proteins/chemistry,genetics,metabolism Neurons/physiology Nuclear Proteins/chemistry,genetics,metabolism Peptides Promoter Regions, Genetic Rats Receptors, Dopamine D2/genetics Solubility Sp1 Transcription Factor/chemistry,metabolism TATA-Binding Protein Associated Factors Transcription Factor TFIID Transcription Factors/chemistry,metabolism Transcription, Genetic Transfection Trinucleotide Repeat Expansion Two-Hybrid System Techniques

DNA-Binding Proteins HTT protein, human Htt protein, mouse Htt protein, rat Huntingtin Protein Nerve Tissue Proteins Nuclear Proteins Peptides Receptors, Dopamine D2 Sp1 Transcription Factor TAF4 protein, human TAF4 protein, mouse TATA-Binding Protein Associated Factors Transcription Factor TFIID Transcription Factors polyglutamine DNA