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PMID: 11988763 Published · ppublish English Journal Article Review

Genealogical trees, coalescent theory and the analysis of genetic polymorphisms.

Nature reviews. Genetics ·Vol. 3 ·No. 5 ·2002-05-00 ·Pages 380-90

Rosenberg NA, Nordborg M

Abstract

Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

MeSH Terms
Animals Evolution, Molecular Genetics, Population Humans Pedigree Polymorphism, Genetic Recombination, Genetic Stochastic Processes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rosenberg Noah A
Program in Molecular and Computational Biology, University of Southern California, 835 West 37th Street, SHS172, Los Angeles, California 90089-1340, USA.
Nordborg Magnus
Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0056
Published
2002-05-00
Pages
380-90
Language
English
Region
England
NLM ID
100962779
Subset
IM
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