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PMID: 11991714 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs.

Genomics ·Vol. 79 ·No. 5 ·2002-05-00 ·Pages 657-62

Osada N, Kusuda J, Hirata M, Tanuma R, Hida M, Sugano S, Hirai M, Hashimoto K

Abstract

It is possible to assess positive selection by using the ratio of K(a) (nonsynonymous substitutions per plausible nonsynonymous sites) to K(s) (synonymous substitutions per plausible synonymous sites). We have searched candidate genes positively selected during primate evolution by using 5'-end sequences of 21,302 clones derived from cynomolgus monkey (Macaca fascicularis) brain cDNA libraries. Among these candidates, 10 genes that had not been shown by previous studies to undergo positive selection exhibited a K(a)/K(s) ratio > 1. Of the 10 candidate genes we found, 5 were included in the mitochondrial respiratory enzyme complexes, suggesting that these nuclear-encoded genes coevolved with mitochondrial-encoded genes, which have high mutation rates. The products of other candidate genes consisted of a cell-surface protein, a member of the lipocalin family, a nuclear transcription factor, and hypothetical proteins.

MeSH Terms
Animals Cytochrome c Group/genetics DNA, Complementary/chemistry,genetics Databases, Nucleic Acid Electron Transport Complex IV/genetics Evolution, Molecular Genes/genetics Macaca fascicularis/genetics Molecular Sequence Data Phylogeny Primates/genetics Selection, Genetic Sequence Analysis, DNA
Chemicals
Cytochrome c Group DNA, Complementary Electron Transport Complex IV
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Osada Naoki
Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, [email protected]
Kusuda Jun
Hirata Makoto
Tanuma Reiko
Hida Munetomo
Sugano Sumio
Hirai Momoki
Hashimoto Katsuyuki
Article Info
Journal
Genomics
Abbr.
Genomics
ISSN
0888-7543
DOI
10.1006/geno.2002.6753
Email
[email protected]
Published
2002-05-00
Pages
657-62
Language
English
Region
United States
NLM ID
8800135
Subset
IM
Databases
GENBANK
AB072015, AB072016, AB072017, AB072018, AB072019, AB072020, AB072021, AB072022, AB072023, AB072024, AB072025, AB072026, AB072312, AB072313, AB072314, AB072315, AB072316, AB072317, AB072318, AB072319, AB072320, AB072321, AB072322, AB072323, AB072324, AB072325, AB072326, AB072327, AB072328, AB072329, AB072330, AB072331
External Links
PubMed source DOI: 10.1006/geno.2002.6753 View journal details
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