6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci.
An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism.
17 references, click to expand
-
Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus).Genetics. 1968 Apr;58(4):599-606 PMID: 5693479
-
Inherited quantitative variations of human phosphogluconate dehydrogenase.Ann Hum Genet. 1967 May;30(4):339-53 PMID: 5619935
-
Molecular size studies on 6-phosphogluconate dehydrogenase.Nature. 1966 Oct 8;212(5058):197-8 PMID: 5972220
-
Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1).Biochem Genet. 1971 Apr;5(2):101-10 PMID: 4397868
-
Erythrocyte phosphogluconate dehydrogenase polymorphism.Nature. 1966 Apr 30;210(5035):487-9 PMID: 5960509
-
Biochemical polymorphisms in feral and inbred mice (mus musculus).Biochem Genet. 1971 Oct;5(5):457-66 PMID: 5520794
-
Linkage data on Rh, PGM1, PGD, Peptidase C and Fy from family studies.Ann Hum Genet. 1973 Apr;36(4):393-9 PMID: 4201296
-
A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.J Histochem Cytochem. 1973 Dec;21(12):1066-81 PMID: 4587225
-
Electrophoretic variation of alpha-amylase in two inbred strains of Mus musculus.J Hered. 1973 May-Jun;64(3):155-7 PMID: 4745489
-
Electrophoretic variation in enzymes.Science. 1965 Aug 27;149(3687):936-43 PMID: 5318249
-
The anatomy and function of a segment of the X chromosome of Drosophila melanogaster.Genetics. 1972 May;71(1):139-56 PMID: 4624778
-
Hexose-6-phosphate dehydrogenase found in human liver.Science. 1966 Aug 26;153(3739):1015-6 PMID: 5917551
-
PROTEIN POLYMORPHISM AND GENIC HETEROZYGOSITY IN TWO EUROPEAN SUBSPECIES OF THE HOUSE MOUSE.Evolution. 1969 Sep;23 (3):379-390 PMID: 28562929
-
Expression of paternal genes during embryogenesis in the viable interspecific hybrid amphibian embryo Rana pipiens female x Rana palustris male. Electrophoretic analysis of five enzyme systems.J Exp Zool. 1971 Nov;178(3):313-8 PMID: 5315654
-
Esterase-8 (Es-8): characterization, polymorphism, and linkage of an erythrocyte esterase locus on chromosome 7 of Mus musculus.Biochem Genet. 1974 May;11(5):347-58 PMID: 4841974
-
Nuclear and cytoplasmic contributions to dehydrogenase phenotypes in hybrid frog embryos.Dev Biol. 1971 Jan;24(1):119-40 PMID: 5315831
-
Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers.Biochem Genet. 1970 Apr;4(2):339-50 PMID: 5424503
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
