Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis.

Adult Base Sequence Calcinosis/complications,diagnosis,genetics Chronic Disease DNA Mutational Analysis Diabetes Complications Female Genetic Predisposition to Disease Humans Male Middle Aged Mutation Pancreatitis/complications,diagnosis,genetics,pathology Phenotype Trypsin Trypsin Inhibitor, Kazal Pancreatic/genetics Trypsinogen/genetics

Trypsin Inhibitor, Kazal Pancreatic Trypsinogen PRSS1 protein, human Trypsin