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PMID: 12036314 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype.

Virology ·Vol. 296 ·No. 1 ·2002-04-25 ·Pages 17-23

Beasley DW, Li L, Suderman MT, Barrett AD

Abstract

Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

MeSH Terms
Age Factors Animals Cricetinae Disease Models, Animal Female Genotype Mice Molecular Sequence Data Phenotype Phylogeny Viral Nonstructural Proteins/genetics Virulence/genetics West Nile Fever/virology West Nile virus/classification,genetics,pathogenicity
Chemicals
NS5 protein, flavivirus Viral Nonstructural Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Beasley David W C
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
Li Li
Suderman Miguel T
Barrett Alan D T
Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1006/viro.2002.1372
Published
2002-04-25
Pages
17-23
Language
English
Region
United States
NLM ID
0110674
Subset
IM
Grants
NIAID NIH HHS · AI10984 · United States
Databases
GENBANK
AF458343, AF458344, AF458345, AF458346, AF458347, AF458348, AF458349, AF458350, AF458351, AF458352, AF458353, AF458354, AF458355, AF458356, AF458357, AF458358, AF458359, AF458360, AF458361
External Links
PubMed source DOI: 10.1006/viro.2002.1372 View journal details
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