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PMID: 12058344 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Parental genotypes in the risk of a complex disease.

American journal of human genetics ·Vol. 71 ·No. 1 ·2002-07-00 ·Pages 193-7

Labuda D, Krajinovic M, Sabbagh A, Infante-Rivard C, Sinnett D

Abstract

Our understanding of the genetic etiology of complex disorders is still elusive. According to the common-variant/common-disease hypothesis, frequent functional polymorphisms are the best candidates for disease-susceptibility alleles. Implicitly, we also assume that disease-susceptibility alleles are preferentially transmitted from parents to the affected offspring and that this effect can be captured by the transmission/disequilibrium test (TDT). However, our study of genetic predisposition to childhood acute lymphoblastic leukemia suggests that a focus on the patient's genotype might, in certain instances, be misleading. Our results indicate that, at least at some loci, parental genetics might be of primary importance in predicting the risk of cancer in this pediatric model of a complex disease. Consequently, in addition to TDT, other complementary strategies will need to be simultaneously applied to dissect genetic predisposition to complex disorders.

MeSH Terms
Case-Control Studies Child Cytochrome P-450 CYP2E1/genetics Female Genotype Glutathione S-Transferase pi Glutathione Transferase/genetics Humans Isoenzymes/genetics Linkage Disequilibrium Male Models, Genetic Parents Pedigree Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology,genetics Risk Factors
Chemicals
Isoenzymes Cytochrome P-450 CYP2E1 GSTP1 protein, human Glutathione S-Transferase pi Glutathione Transferase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Labuda Damian
Centre de recherche, Hôpital Sainte Justine, Université de Montréal, Québec, H3T 1C5 Canada. [email protected]
Krajinovic Maja
Sabbagh Audrey
Infante-Rivard Claire
Sinnett Daniel
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/341345
Email
[email protected]
Published
2002-07-00
Epub
2002-00-07
Pages
193-7
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC384979
Subset
IM
Databases
OMIM
124040, 134660
Corrections
CommentIn
PMID: 12452177
CommentIn
PMID: 12452178
External Links
PubMed source DOI: 10.1086/341345 PMC Full Text View journal details
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