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PMID: 12061893 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.

The Biochemical journal ·Vol. 366 ·No. Pt 2 ·2002-09-01 ·Pages 377-91

Foufelle F, Ferré P

Abstract

The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels, including a transcriptional level, since many of the metabolism-related genes are expressed according to the quantity and quality of nutrients. Recent advances have been made in the understanding of the regulation of hepatic glycolytic, lipogenic and gluconeogenic gene expression by pancreatic hormones, insulin and glucagon and glucose. Here we review the role of the transcription factors forkhead and sterol regulatory element binding protein-1c in the inductive and repressive effects of insulin on hepatic gene expression, and the pathway that leads from glucose to gene regulation with the recently discovered carbohydrate response element binding protein. We discuss how these transcription factors are integrated in a regulatory network that allows a fine tuning of hepatic glucose storage or production, and their potential importance in metabolic diseases.

MeSH Terms
Animals CCAAT-Enhancer-Binding Proteins/metabolism DNA-Binding Proteins/metabolism Gene Expression Regulation/drug effects Glucose/metabolism,pharmacology Glycolysis/drug effects,genetics Homeostasis Humans Insulin/pharmacology Liver/metabolism Sterol Regulatory Element Binding Protein 1 Transcription Factors/metabolism
Chemicals
CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins Insulin SREBF1 protein, human Sterol Regulatory Element Binding Protein 1 Transcription Factors Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Foufelle Fabienne
INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. [email protected]
Ferré Pascal
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/BJ20020430
Email
[email protected]
Published
2002-09-01
Pages
377-91
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1222807
Subset
IM
External Links
PubMed source DOI: 10.1042/BJ20020430 PMC Full Text View journal details
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