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PMID: 12067496 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Fibroblast growth factors in myocardial ischemia / reperfusion injury and ischemic preconditioning.

Journal of cellular and molecular medicine ·Vol. 5 ·No. 2 ·2001-00-00 ·Pages 132-42

Cuevas P, Carceller F, Giménez-Gallego G

Abstract

Angiogenic growth factors such as fibroblast growth factors (FGFs) are currently in clinical trials for accelerating blood vessel formation in myocardial and limb ischemic conditions. However, recent experimental evidence suggests that FGFs can also participate as endogenous cardioprotective agents. In this report, the current knowledge for FGFs implication in myocardial ischemic tolerance will be summarized. Pharmacologic preconditioning with drugs as FGFs that mimic the beneficial effects of ischemic preconditioning could lead to novel therapeutic approaches for the treatment of ischemic disorders including myocardial infarction and stroke.

MeSH Terms
Animals Fibroblast Growth Factors/metabolism,physiology Humans Ischemic Preconditioning, Myocardial Models, Biological Myocardium/pathology Rats Reperfusion Injury/metabolism
Chemicals
Fibroblast Growth Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cuevas P
Department of Research, Ramón y Cajal Hospital, Madrid, Spain. [email protected]
Carceller F
Giménez-Gallego G
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Article Info
Journal
Journal of cellular and molecular medicine
Abbr.
J Cell Mol Med
ISSN
1582-1838
DOI
10.1111/j.1582-4934.2001.tb00146.x
Email
[email protected]
Published
2001-00-00
Pages
132-42
Language
English
Region
England
NLM ID
101083777
PMCID
PMC6517810
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1582-4934.2001.tb00146.x PMC Full Text View journal details
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