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PMID: 12076048 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Polymorphism in the rhesus macaque (Macaca mulatta) NRAMP1 gene: lack of an allelic association to tuberculosis susceptibility.

Journal of medical primatology ·Vol. 31 ·No. 1 ·2002-02-00 ·Pages 8-16

Deinard AS, Lerche NW, Smith DG

Abstract

Although previous tuberculosis (TB) research has suggested that underlying genetic factors influence a host's response and ability to survive Mycobacterium infection, only recently has a gene been identified, the 'natural resistance-associated macrophage protein 1' (NRAMP1) gene, which provides a degree of natural resistance to infection by some Mycobacterium species. To date, however, the role that NRAMP1 may play in resistance to Mycobacterium infection has only been examined in mouse and man. Here, we present data generated at NRAMP1 among a group of rhesus macaques (Macaca mulatta) that were euthanized because of an outbreak of Mycobacterium tuberculosis during quarantine. Data were also generated on unrelated (and healthy) rhesus macaques in order to better determine the frequency and degree of genetic polymorphism within Macaca at the NRAMP1 locus. These data represent the first study designed to examine the role that NRAMP1 may play in TB susceptibility among rhesus macaques.

MeSH Terms

Alleles Animals Base Sequence Cation Transport Proteins/genetics Genetic Predisposition to Disease Macaca mulatta/genetics Molecular Sequence Data Mycobacterium tuberculosis/pathogenicity Polymerase Chain Reaction Polymorphism, Genetic Sequence Analysis, DNA Tuberculosis/genetics,veterinary

Chemicals

Cation Transport Proteins natural resistance-associated macrophage protein 1

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Deinard Amos S

School of Veterinary Medicine, and Department of Anthropology, University of California, Davis 95616, USA. [email protected]

Lerche Nicholas W

Smith David Glenn

Article Info

Journal

Journal of medical primatology

Abbr.

J Med Primatol

ISSN

0047-2565

DOI

10.1034/j.1600-0684.2002.1o022.x

[email protected]

Published

2002-02-00

Pages

8-16

Language

English

Region

Denmark

NLM ID

0320626

Subset

Grants

NCRR NIH HHS · RR00169 · United States

NCRR NIH HHS · RR05090 · United States

Databases

GENBANK

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PubMed source DOI: 10.1034/j.1600-0684.2002.1o022.x View journal details

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Polymorphism in the rhesus macaque (Macaca mulatta) NRAMP1 gene: lack of an allelic association to tuberculosis susceptibility.

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