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PMID: 12081799 Published · ppublish English Journal Article Review

A review on SNP and other types of molecular markers and their use in animal genetics.

Genetics, selection, evolution : GSE ·Vol. 34 ·No. 3 ·2002-00-00 ·Pages 275-305

Vignal A, Milan D, SanCristobal M, Eggen A

Abstract

During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.

MeSH Terms
Alleles Animals Animals, Domestic/genetics Base Sequence Biometry DNA/genetics Female Genetic Markers Genetic Techniques Genetics, Population Genome, Human Humans Male Microsatellite Repeats Molecular Biology Polymorphism, Single Nucleotide Quantitative Trait, Heritable
Chemicals
Genetic Markers DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Vignal Alain
Laboratoire de génétique cellulaire, Inra, chemin de Borde-Rouge, Auzeville BP 27, 31326 Castanet-Tolosan cedex, France. [email protected]
Milan Denis
SanCristobal Magali
Eggen André
Article Info
Journal
Genetics, selection, evolution : GSE
Abbr.
Genet Sel Evol
ISSN
0999-193X
Published
2002-00-00
Pages
275-305
Language
English
Region
France
NLM ID
9114088
PMCID
PMC2705447
Subset
IM
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