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PMID: 12081978 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli.

Journal of bacteriology ·Vol. 184 ·No. 14 ·2002-07-00 ·Pages 4044-7

Walt A, Kahn ML

Abstract

In Escherichia coli, the use of carnitine as a terminal electron acceptor depends on a functional caiTABCDE operon. It had been suggested that the adjacent but divergent fixABCX operon is also required for carnitine metabolism, perhaps to provide electrons for carnitine reduction. We have constructed E. coli fixA and fixB mutants and find that they are unable to reduce carnitine to gamma-butyrobetaine under anaerobic conditions.

MeSH Terms

Anaerobiosis Bacterial Proteins/genetics Betaine/analogs & derivatives,metabolism Carnitine/metabolism Escherichia coli/genetics,growth & development Escherichia coli Proteins Flavoproteins Oxidation-Reduction

Chemicals

Bacterial Proteins Escherichia coli Proteins FixA protein, E coli Flavoproteins fixB protein, E coli Betaine gamma-butyrobetaine Carnitine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Walt Angelique

Institute of Biological Chemistry and School of Molecular Biosciences, Washington State University, Pullman 99164-6340, USA.

Kahn Michael L

References (12)

12 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/JB.184.14.4044-4047.2002

Published

2002-07-00

Pages

4044-7

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC135185

Subset

External Links

PubMed source DOI: 10.1128/JB.184.14.4044-4047.2002 PMC Full Text View journal details

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The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli.

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