Cyclins in breast cancer: too much of a good thing.

Breast cancer research : BCR ·Vol. 4 ·No. 4 ·2002-00-00 ·Pages 145-7

Enders GH

Abstract

Cyclin E, a key mediator of entry into the cell division cycle, is expressed abundantly in many breast cancers. However, amplification of the cognate gene is observed rarely, leaving the responsible mechanism(s) and its importance in tumorigenesis in doubt. In a recent report, Steve Reed's lab demonstrates that hCdc4/Fbw7 targets cyclin E for ubiquitin-mediated proteolysis and is mutant in a breast cancer cell line with high cyclin E levels. Independent work demonstrates that a Drosophila hCdc4 homologue constrains cyclin E expression in vivo. These results suggest that lesions in protein degradation pathways may contribute to cyclin E deregulation in breast cancer.

MeSH Terms

Breast Neoplasms/metabolism,pathology Cell Cycle Cell Cycle Proteins/genetics,physiology Cell Line, Transformed Cyclins/metabolism F-Box Proteins F-Box-WD Repeat-Containing Protein 7 Female Fungal Proteins/metabolism Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans Neoplasm Proteins/metabolism Phosphorylation Protein Processing, Post-Translational Saccharomyces cerevisiae/cytology,metabolism Saccharomyces cerevisiae Proteins/genetics,physiology Tumor Cells, Cultured Ubiquitin-Protein Ligases

Chemicals

CDC4 protein, S cerevisiae Cell Cycle Proteins Cyclins F-Box Proteins F-Box-WD Repeat-Containing Protein 7 FBXW7 protein, human Fungal Proteins Neoplasm Proteins Saccharomyces cerevisiae Proteins Ubiquitin-Protein Ligases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Enders Greg H

Penn/GI Division, Suite 600/CRB, 415 Curie Boulevard, Philadelphia, PA 19104-6144, USA. [email protected]

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Article Info

Journal

Breast cancer research : BCR

Abbr.

Breast Cancer Res

ISSN

1465-5411

DOI

10.1186/bcr439

[email protected]

Published

2002-00-00

Epub

2002-00-07

Pages

145-7

Language

English

Region

England

NLM ID

100927353

PMCID

PMC138734

Subset

External Links

PubMed source DOI: 10.1186/bcr439 PMC Full Text View journal details

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Cyclins in breast cancer: too much of a good thing.

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